EGF receptor (EGFR) inhibition promotes a slow-twitch oxidative, over a fast-twitch, muscle phenotype
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چکیده
منابع مشابه
Phenotype into the Fast-Twitch Phenotype Adult Muscle from the Slow-Twitch Six1 and Eya1 Expression Can Reprogram
10.1128/MCB.24.14.6253-6267.2004. 2004, 24(14):6253. DOI: Mol. Cell. Biol. Pascal Maire Petrof, Dominique Daegelen, Jean-Paul Concordet and Kiyoshi Kawakami, Pin-Xian Xu, Robert Kelly, Basil J. Lopez, Josiane Demignon, Jacques-Emmanuel Guidotti, Raphaelle Grifone, Christine Laclef, François Spitz, Soledad Phenotype into the Fast-Twitch Phenotype Adult Muscle from the Slow-Twitch Six1 and Eya1 E...
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A study has been made of the isometric twitches of single motor units in the extensor hallucis brevis (EHB) muscle in man. The twitch contraction times ranged from 35 to 98 msec and the pooled results indicated the presence of at least two types of unit. The recorded twitch tensions also varied considerably (from 2 to 14 g) but were not related to the twitch speeds. The twitch tension developed...
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Smaller diaphragmatic motor unit potentials (MUPs) compared to MUPs of limb muscles lead to the hypothesis that diaphragmatic muscle fibers, being the generators of MUPs, might be also smaller. We compared autopsy samples of costal diaphragm and vastus lateralis of healthy men with respect to fibers' size and expression of slow myosin heavy chain isoform (MyHC-1) and fast 2A isoform (MyHC-2A). ...
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Chronic hypoxia alters respiratory muscle force and fatigue, effects that could be attributed to hypoxia and/or increased activation due to hyperventilation. We hypothesized that chronic hypoxia is associated with phenotypic change in non-respiratory muscles and therefore we tested the hypothesis that chronic hypobaric hypoxia increases limb muscle force and fatigue. Adult male Wistar rats were...
متن کاملIntracellular calcium movements during excitation–contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers
In skeletal muscle fibers, action potentials elicit contractions by releasing calcium ions (Ca(2+)) from the sarcoplasmic reticulum. Experiments on individual mouse muscle fibers micro-injected with a rapidly responding fluorescent Ca(2+) indicator dye reveal that the amount of Ca(2+) released is three- to fourfold larger in fast-twitch fibers than in slow-twitch fibers, and the proportion of t...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-45567-4